CORDIS Project
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This project investigates the role of the RNA helicase HELZ in the oxygen-sensing mechanism involving prolyl-4-hydroxylase domain proteins. It aims to understand how HELZ interacts with these proteins and its implications in tumor development and other diseases by creating a targeted gene model for in vivo studies.
A crucial step in the adaptation of mammalian cells to oxygen deficiency is the transcriptional activation of hypoxia-inducible genes.
Hypoxia-inducible transcription factors (HIFs) are master regulators for the up-regulation of these genes under physiological as well as pathophysiological conditions, such as tumor development and metastasis, cardiovascular diseases and inflammation. HIFs are O2-dependently hydroxylated at conserved prolyl residues by recently discovered prolyl-4-hydroxylase dom…
University of Zurich
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