CORDIS Project
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This project investigates how reduced microbial exposure affects immune development and the rise of immune-mediated disorders like allergies and autoimmunity. Using advanced animal models, it aims to uncover the immunological mechanisms involved, ultimately guiding preventive strategies against these diseases.
Immune-mediated disorders such as allergy and autoimmunity are major public health problems.
In the past 40 years the incidence of these diseases has risen dramatically in developed countries.
Epidemiological studies have revealed a clear correlation between disease susceptibility and improvements in hygiene.
For example, children with older siblings show a reduced prevalence of asthma, multiple sclerosis (MS), and Type 1 diabetes (T1D), and infants (<1year) that attend daycare centers show redu…
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