CORDIS Project
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The HYPER-INSIGHT project investigates hypermutated tumors to understand the mechanisms of mutations in cancer. It focuses on DNA replication and repair processes, aiming to identify potential therapeutic targets for hypermutated cancer cells.
Mutations are the fuel of any evolutionary process, and this also applies to carcinogenesis.
The advent of affordable DNA sequencing has enabled mutagenic processes in the human soma to be quantified genome-wide, revealing a striking occurrence of hypermutated tumors.
They exhibit an extreme load of somatic changes, often harbouring hundreds of single-nucleotide variants and/or indels per megabase.
The HYPER-INSIGHT project is organized into three objectives, which aim to take advantage of the u…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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