CORDIS Project
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This project aims to improve the synthesis of radiolabeled compounds for imaging hypoxia in medical applications. It focuses on developing a new method for fluorinating specific alkyl chains and automating the production of radiolabeled biomarkers for pre-clinical studies.
The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains.
We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride.
The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5.
We propose to develop an a…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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