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The HYPOXIA project investigates the molecular mechanisms regulating erythropoietin (EPO) gene expression, focusing on naturally occurring mutations linked to increased red blood cell production. By utilizing human induced pluripotent stem cells, the project aims to understand EPO regulation and its potential therapeut…
Cellular adaptation to oxygen deficiency (hypoxia) is a complex biological process.
Germline mutations occurring in the hypoxia genes pathway provided major information to dissect the molecular mechanisms regulating this pathway.
The objective of HYPOXIA project is to elucidate the molecular and regulatory mechanisms governing erythropoietin (EPO) gene expression, a major actor of the hypoxia pathway.
The originality of HYPOXIA lies in identifying naturally occurring germline EPO mutations in pa…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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