CORDIS Project
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This project focuses on developing targeted cancer therapies that activate under low oxygen conditions in solid tumors. It aims to create hypoxia-activated inhibitors for key cancer-related enzymes and improve imaging techniques for hypoxic tumors using novel fluorescent probes.
Solid tumours contain hypoxic cells, which exist at a low oxygen tensions and are resistant to chemotherapy and radiotherapy.
Although problematic for therapy, any quality that distinguishes tumour cells from healthy ones presents an opportunity for targeting therapies.
We have begun developing prodrugs that selectively release inhibitors of cancer-related enzymes under hypoxia.
In this project, we will develop hypoxia-activated inhibitors of the checkpoint kinase, Chk1, which is an important ch…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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