CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project explores the mechanisms behind the recognition and anchoring of lamina-associated domains (LADs) in the human genome, focusing on their nucleotide composition and the role of the cohesin complex in genome organization. It aims to develop a new technique for analyzing LAD sequences and their influence on ge…
Lamina-associated domains (LADs) are large chromatin domains anchored to a protein meshwork coating the inner nuclear envelope, the nuclear lamina (NL).
They cover 40% of the human genome and hold thousands of transcriptionally repressed genes.
While some LADs can be locally detached from the NL upon gene activation, others are constitutively at the NL.
This implies that LAD recognition and anchoring to the NL has to be tightly regulated to ensure acute gene expression.
However, little is known…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
Guests see up to 5 keywords.
