CORDIS Project
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This project aims to create a comprehensive map of the innate immune system's molecular components involved in viral detection and response. It combines large-scale proteomics with functional studies to identify key interactions and mechanisms that could lead to new treatments for autoimmune diseases and enhance antivi…
After a decade of development in model organisms and later in mammalian cells, mass spectrometry-based functional proteomics approaches have come of age and are ready to enable a systematic study of the innate immune system.
We propose to cross the large-scale proteomics and innate immunity disciplines to obtain a functionally annotated map of the molecular machinery involved in viral recognition and leading to the hallmark interferon response, through a three-pronged approach: 1.
Map the intera…
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