CORDIS Project
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This project investigates how microRNA influences the differentiation of CD4+ T lymphocyte subsets, which play a crucial role in immune responses. By profiling microRNA signatures in serum, the research aims to identify new therapeutic targets for immune-mediated diseases and develop diagnostic tools.
Background:
CD4+ T lymphocyte subsets orchestrate immune responses in health and disease.
Little is known on control of T cell differentiation exerted by microRNA that affect mRNA translation.
The identification of microRNA and their targets that regulate differentiation of T cell subsets may provide new therapeutic targets for immune-mediated diseases.
Since microRNA are released in exosomes and circulate in blood, activities of tissue-derived lymphocytes could be assessed by microRNA signature…
UNIVERSITA DEGLI STUDI DI MILANO
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