CORDIS Project
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The project aims to develop i-SignalTrace, a CRISPR/Cas9-based tool for recording cellular signaling events during stem cell differentiation. It will enable the analysis of how extracellular signals influence gene expression and cell fate, providing insights for advanced cellular therapies in regenerative medicine.
Understanding the identity and intensity of the specific extracellular signals that a cell experiences at different times during its differentiation is essential to develop advanced cellular therapies.
However, uncovering the sequence of these signaling events, their intensities, timing, and relevance in development and disease is proving to be very challenging.Here, I propose to build i-SignalTrace: a CRISPR/Cas9-based molecular recorder with the capacity to store both lineage information and s…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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