CORDIS Project
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This project investigates a newly discovered system of antibody-mediated immunity that operates inside infected cells. By focusing on the cytosolic antibody receptor TRIM21, the research aims to understand its role in targeting and degrading virus-infected cells, potentially leading to innovative antiviral therapies.
Antibodies are a critical component of immune defence but they provide purely extracellular protection – once inside a cell, a pathogen is safe.
This is the view of humoral immunity that has existed for over 100 years.
However, recent work in my lab has led to the discovery of a missing system of antibody-mediated immunity that takes place inside infected cells. I have identified a novel cytosolic antibody receptor (TRIM21) that binds to antibody-coated viruses after cellular infection and targe…
MEDICAL RESEARCH COUNCIL
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