CORDIS Project
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This project investigates how calcium ions regulate the secretion of mucins from goblet cells in the airways and gastrointestinal tract. By using advanced genetic and imaging techniques, it aims to fill gaps in understanding mucin physiology, which is critical for maintaining epithelial health and preventing diseases l…
The epithelium in the airways and gastrointestinal track are covered by a mucus layer which protects the epithelium from mechanical and microbial insults.
The most abundant proteins in the mucus layer are mucins which are synthesized and secreted by goblet cells.
Mucus function is largely dictated by mucin composition and goblet cells can modify their secretory properties to adapt to the continuous changes the epithelium is encountered with.
Mucins are heavily glysosylated and packed into secret…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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