CORDIS Project
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This project focuses on understanding how ion channels operate by examining their structures and mechanisms of activation. Using advanced imaging techniques, the research aims to observe the real-time conformational changes of these channels when modulated by specific ligands.
Our understanding of ion channel operation is limited to inferences based on functional data and to static snapshots of their structures where they are available.
Cyclic nucleotide-modulated channels and calcium-activated K+ channels play crucial roles in a myriad of physiological processes ranging from signal transduction to neuronal excitability.
The binding of ligands to specialized intracellular domains modulates the opening/closing (gating) equilibrium of these channels.
Both the high resol…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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