CORDIS Project
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The iCARUS project develops an innovative CAR T cell therapy to treat autoimmune diseases like rheumatoid arthritis and multiple sclerosis. This approach selectively targets harmful immune cells while delivering anti-inflammatory agents locally, aiming for effective disease management without systemic side effects.
Autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS) result in chronic pain, disability, and major socioeconomic burden, with estimated 20.9 million RA patients globally.
Despite significant therapeutic advances, up to 20% of RA cases remain refractory, and MS frequently progresses despite treatment.
Current therapies rely on systemic immunosuppression, require chronic dosing, and inadequately target tissue-resident pathogenic immune cells - resulting in persistent i…
WEIZMANN INSTITUTE OF SCIENCE
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