CORDIS Project
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This project investigates the secretion and release mechanisms of Wingless, a signaling protein involved in development and cancer. By identifying proteins essential for its secretion, the research aims to enhance understanding of Wingless function and its signaling pathways, which could inform therapeutic strategies.
Wnts are secreted signaling proteins that control multiple developmental processes and have been implicated in several human cancers.
All Wnt proteins, including Wingless, a Drosophila member of the Wnt family, associate with cell membranes.
This membrane-association is a result of posttranslational acylation and strong affinity for heparin sulfate proteoglycans.
Despite its association with cell membranes, Wingless acts over several cell diameters in a number of developmental contexts.
It has b…
MEDICAL RESEARCH COUNCIL
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