CORDIS Project
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This project aims to develop small-molecule activators of the PI3K delta isoform to induce cell death in cancer cells. By understanding the activation mechanism and testing these compounds in hematological malignancies, the research seeks to advance cancer therapy and improve drug development strategies.
PI3K signalling is a critical regulator of many cellular functions including cell growth and survival, and is deregulated in cancer and auto-immunity.This proposal is based on the concept to cause cell death by hyperactivating signalling in cancer cells above a tolerable threshold.
This idea has been previously proposed for other kinases, but no small-molecule activators were available to formally test the idea.
This proposal focuses on activators of the leukocyte-enriched PI3Kd, an isoform of P…
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