CORDIS Project
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This project aims to uncover new interactions and potential drug targets in the signaling pathways of the Epidermal Growth Factor Receptor, particularly its cancerous variants. By employing a novel two-hybrid technique, the research seeks to identify compounds that can disrupt these interactions, ultimately contributin…
One of the major challenges of modern molecular biology is to understand how healthy cells transform into malignant, proliferating cells leading to diseases such as cancer and which proteins trigger these aberrant signalling cascades.
The ErbB family of receptor tyrosine kinases (RTKs) are pivotal mediators of the signalling network that transmit extracellular signals into the cell and control cell growth, proliferation, differentiation and survival.
Excessive ErbB signalling arises from recepto…
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