CORDIS Project
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This research focuses on the GPR101 gene's role in regulating growth and its link to pituitary tumors in children. The project aims to uncover the molecular mechanisms behind GPR101 overexpression and its effects on chromatin structure and transcriptional regulation.
There is a fundamental gap in understanding how the GPR101 gene regulates human growth in physiological and pathological conditions.
Children’s growth is remarkably clinical relevant and is an important indicator of their health and general well-being.
The specific objective of this proposal is to identify the molecular mechanisms underlying GPR101 overexpression in the pituitary tumors of children with GPR101 duplications causing X-linked acrogigantism (X-LAG).My central hypothesis is that GPR1…
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