CORDIS Project
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This project investigates how dendritic cells regulate immune responses through their metabolism. It aims to characterize the metabolic profiles of dendritic cells that polarize T helper cells and explore how manipulating these metabolic states can enhance immunotherapy.
Dendritic cells (DCs) are key regulators of both immunity and tolerance by controlling activation and polarization of effector T helper cells (Th) and regulatory T cell responses (Treg).
Therefore, there is a major focus on developing approaches to manipulate DC function for immunotherapy.
It is well known that changes in cellular activation are coupled to changes in cellular metabolism.
However, only recently, based on studies with T cells and macrophages, the picture is emerging that manipulat…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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