CORDIS Project
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The project focuses on understanding the mechanisms of metastasis in pancreatic cancer, particularly those driven by genetic mutations. It aims to identify genes that influence cancer spread and explore potential treatments targeting these pathways.
Pancreatic cancer is one of the leading causes of cancer-associated mortality.
One of the primary contributing factors is late diagnosis of the disease, resulting in established metastatic cancer before symptoms emerge.
This form of cancer is characterised by a number of well-defined genetic alterations including oncogenic mutation of K-Ras and inactivating mutation of p53, SMAD4 and CDKN2A.
Concurrent deregulation of K-ras and these tumor suppressors facilitates uncontrolled proliferation of…
CANCER RESEARCH UK LBG
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