CORDIS Project
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This project investigates the role of Rab GTPase proteins in post-Golgi trafficking within mammalian cells. It aims to identify Rab GTPase cascades that coordinate transport steps to enhance our understanding of membrane traffic, which is crucial for studying diseases like cancer and neurological disorders.
Throughout the last thirty years, research on Rab GTPase proteins has brought light to their pivotal role in the regulation of several steps of intracellular trafficking.
However, recent findings indicate that Rab proteins not only regulate individual transport steps, but they also function in a coordinated fashion in Rab GTPase cascades.
Such cascades appear to be crucial for orchestrating sequential steps along transport pathways and for ensuring continuity in membrane traffic.
Rab cascades h…
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