CORDIS Project
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This project investigates the genetic factors influencing rheumatoid arthritis and Crohn's disease by examining how specific genetic variants affect gene regulation. The research aims to identify key cell types and regulatory elements impacted by these variants to discover new therapeutic targets.
Rheumatoid Arthritis (RA) and Crohn’s disease (CD) are two common chronic autoimmune and complex diseases where individual susceptibility is determined by a combination of environmental and genetic factors.
Almost all of the ~100 risk alleles discovered through recent genetic studies fall in non-coding region and have an elusive function.
We hypothesize that risk alleles impact gene regulation by altering regulatory elements (e.g. enhancers) controlling the expression levels of genes within the…
UNIVERSITE DE LIEGE
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