CORDIS Project
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This project investigates the role of lung epithelial stem cells and their interactions with endothelial cells in pulmonary fibrosis. It aims to understand how these interactions influence tissue repair and regeneration, potentially leading to new therapies for this debilitating disease.
Pulmonary fibrosis is a multifaceted and fatal disease that includes damaged alveolar epithelial cells and disorganization of multiple stromal cells.
Dysregulation of multicellular crosstalk between epithelial and stromal cells is likely to contribute to fibrosis.
However, the precise way this tissue damage occurs is unknown. I hypothesize that impaired function of lung epithelial stem cell lead to alveolar epithelial damage in pulmonary fibrosis, and which may be caused by altered stromal/niche…
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