CORDIS Project
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This project investigates how neurons regulate the expression and localization of ion channels, which are crucial for neuronal excitability. It focuses on understanding the molecular mechanisms that influence the assembly and targeting of sodium and potassium channels in key neuronal compartments.
The electrical excitability is a fundamental property of neurons.
Diversity in intrinsic neuronal excitability is generated by the variable expression, subcellular localization, and function of a complex repertoire of ion channels.
Dynamic regulation of intrinsic excitability can further alter the behavior of neurons and confer plasticity to neuronal signaling.
Aberrant expression, localization, and function of ion channels can result in channel-based pathophysiologies.
One of the challenging qu…
UNIVERSITE D'AIX MARSEILLE
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