CORDIS Project
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This project focuses on understanding the genetic factors contributing to Type 2 diabetes by investigating the role of Sirtuin 1 in gene regulation. It aims to identify target genes influenced by Sirtuin 1 and evaluate their impact on diabetes through genetically engineered animal models.
Type 2 diabetes is the most common metabolic disease and is characterized by insulin resistance in the liver, adipose tissue and skeletal muscle and impaired insulin secretion.
Type 2 diabetes is a polygenic disorder which also involves environmental factors and is tightly correlated with obesity.
Therefore, the identification of the genes associated with increased susceptibility to these diseases is difficult.
At present, therapies for this disease are not completely effective and present secon…
UNIVERSITAT AUTONOMA DE BARCELONA
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