CORDIS Project
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This project investigates a specific T cell receptor that is prevalent in individuals infected with human cytomegalovirus and its potential role in detecting cancer cells. The goal is to identify the ligand for this receptor, which could lead to advancements in cancer immunotherapy.
gd T cells are the prototype of unconventional T cells and play an important role in the protection against infections and cancer.
The group of David Vermijlen has recently discovered a human Vg8Vd1 T cell receptor (TCR) which was highly enriched in every individual (therfore ""public"") infected in utero with human cytomegalovirus (HCMV), and that reacts towards adult cancer cells, suggesting that it can detect signals of ""cellular stress"" induced in both infections and cell transformation. T…
UNIVERSITE LIBRE DE BRUXELLES
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