CORDIS Project
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This project focuses on understanding how DNA double-strand breaks are repaired in lymphocytes, particularly during immune responses. It employs advanced techniques to identify chromatin-bound proteins involved in DNA damage repair, aiming to uncover mechanisms that prevent genomic instability and inform cancer therapy…
DNA double-strand breaks (DSBs) in our genome that are not repaired properly can lead to various developmental, immunological, and neurological disorders and are a major driver for genomic instability and tumorigenesis.
The role of chromatin accessibility is of key importance to understand how the DNA/chromatin template senses and amplifies the DNA damage signal to properly repair the DNA in its native context.
While all cells employ mechanisms for repairing DSBs, lymphocytes have uniquely adapt…
KOBENHAVNS UNIVERSITET
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