CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project focuses on understanding the role of the RNF4 protein in DNA repair mechanisms, particularly its interaction with ubiquitin and SUMO pathways. By identifying RNF4 targets and their functions, the research aims to enhance knowledge of DNA damage response.
The Ubiquitin (UB) and SUMO modification pathways have recently been shown to be important regulators of genome stability.
However, despite their significance, we do not have a detailed understanding of which repair proteins they modify, nor how they promote DNA repair.
This proposal aims to address this by studying the human protein RNF4, which sits at the interface between the UB and SUMO pathways. RNF4 is a SUMO targeted ubiquitin ligase (STUbL) which binds poly-SUMOylated chains and ubiquity…
UNIVERSITY OF DUNDEE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
