CORDIS Project
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This project investigates the genetic mutations in kidney cells that may lead to cancer. By analyzing urine samples, it aims to identify cancer-prone cells and understand the mechanisms behind excessive mutations, particularly focusing on the role of low-oxygen conditions and DNA repair pathways.
Understanding what makes our cells prone to develop cancer is key for identifying effective strategies of tumor prevention.
By analyzing the genome of normal human cells, I obtained compelling evidence that the pattern of somatic mutations can be used to identify the cell-of-origin of kidney cancer.
Although every cell accumulates somatic mutations during a lifetime, some are exposed to a specific mutational process that leave a detectable mark in their genome.
Kidney cancers and their cell-of-o…
UNIVERSITA VITA-SALUTE SAN RAFFAELE
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Italy, Milano
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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