CORDIS Project
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This project investigates the mechanisms of drug resistance in parasitic nematodes, focusing on how these organisms uptake macrocyclic lactones like ivermectin. By studying the sensory organs involved in drug absorption, the research aims to develop strategies to combat resistance and improve treatment efficacy in vete…
The macrocyclic lactones such as ivermectin are the cornerstone for the treatment of key nematode infections of livestock, crops and man.
Resistance to many of these broad-spectrum anthelmintics is becoming commonplace, while new classes of active compounds are increasingly difficult to find, threatening food supplies and public heatlh worldwide.
The exact molecular and biochemical mechanisms of resistance, particularly to the widely used macrocyclic lactone class, are still poorly understood, i…
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