CORDIS Project
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This project investigates the immune response triggered by stress-antigens in epithelial cells, focusing on the role of MICA polymorphism in activating T cells and natural killer cells. It aims to understand implications for cancer and inflammatory diseases.
It is increasingly clear that physico-chemical dysregulation of epithelial cells leads to the upregulation of stress-antigens that make the cells visible to sets of lymphocytes that include gamma delta T cells and NK cells.
This form of stress-surveillance can make significant contributions to tumour immunology; transplant rejection; and inflammatory diseases. A central molecular axis underpinning stress-surveillance is the recognition of stress-regulated MHC-I-related molecules, such as MICA an…
CANCER RESEARCH UK LBG
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