CORDIS Project
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This project investigates how type I interferons activate different cellular responses through their receptor dynamics. By employing systems biology, it aims to understand the molecular mechanisms of signaling and develop interferon variants for medical applications, such as enhancing cancer vaccine efficacy.
Type I interferons (IFNs) form a restricted network of highly related immune cytokines that elicit differential biological responses through a single cell surface receptor comprised of the subunits IFNAR1 and IFNAR2.
We have shown that differential signal activation correlates with differential interaction and conformational dynamics of the receptor induced by binding of different member of the IFN family.
The goal of this project is to employ a systems biology approach to identify the molecular…
UNIVERSITAET OSNABRUECK
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Israel, Rehovot
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Switzerland, Zuerich
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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