CORDIS Project
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This project aims to develop a genetically engineered mouse model of lung cancer that mimics human immunogenic tumors. It will explore new therapies and mechanisms to enhance immune responses against lung cancer.
Many studies have recently archived a remarkable clinical efficacy of immunotherapeutic treatments in several cancers including non-small cell lung cancer (NSCLC).
However, these approaches are not always successful and it is currently impossible to predict a therapeutic response or serious adverse event.
These fundamental issues need to be addressed and, to recapitulate the complexity of interactions between immune cells and cancer, this has to be done in vivo.
However, genetically engineered m…
THE FRANCIS CRICK INSTITUTE LIMITED
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