CORDIS Project
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This project focuses on the insulin-like growth factor-1 receptor's role in cancer, particularly hepatocellular carcinoma. It investigates its function as a transcription factor and its interactions with the cell cycle, aiming to develop targeted cancer therapies.
The insulin-like growth factor-1 receptor (IGF-1R) is a cell surface receptor kinase being vastly expressed in malignant tissues and plays crucial roles in growth and survival of cancer cells.
Targeting IGF-1R is pharmaceutically today a very attractive concept.
Larsson’s group at KI has contributed extensively to the current knowledge about IGF-1R and demonstrated that the cyclolignan PPP inhibits IGF-1R signaling.
An oral IGF-1R inhibitor of cyclolignan chemistry is presently studied in patien…
KAROLINSKA INSTITUTET
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