CORDIS Project
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This project investigates the role of IgG4 autoantibodies in autoimmune diseases, focusing on their unique properties and mechanisms. By studying MuSK myasthenia gravis, it aims to identify the environmental factors driving IgG4 responses and develop targeted therapies to reduce harmful IgG4 activity.
The predominant autoantibody (sub)class is an important determinant in the pathophysiology of autoimmune diseases (AID).
Autoantibodies can be pro-inflammatory, such as IgG1, causing disease by complement-mediated or immune cell-mediated tissue damage.
In 2015 I was the first to describe a second group of AID where IgG4 autoantibodies, which are largely unable to activate the immune system, cause disease.
Till date at least 29 different diseases classify as IgG4-predominated AID (IgG4-AID).
Why…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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