CORDIS Project
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The IGN project investigates how intestinal gluconeogenesis influences energy balance and glucose production through neural mechanisms. It aims to identify new metabolites that can activate this process, potentially leading to innovative treatments for obesity and type 2 diabetes.
Obesity and type 2 diabetes continuously progress worldwide, compromising healthy aging.
Deregulated endogenous glucose production (EGP) is involved in hyperglycemia and its complications.
Among the 3 organs (liver, kidney, intestine) contributing to EGP, I uncovered with my team that intestinal gluconeogenesis (IGN) has the capacity to interfere in the control of energy homeostasis.
Indeed, intestinal glucose initiates a gut-brain circuit controlling both body weight and glucose production by t…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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