CORDIS Project
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This project seeks to identify new genetic factors contributing to breast cancer susceptibility in individuals with strong family histories but without known mutations. By combining advanced sequencing techniques, it aims to uncover rare genetic variants that could inform cancer risk assessments.
Background:
Hereditary cancer is an important cause of morbidity and mortality and over the last 20 years, the majority of highly penetrant risk alleles such as BRCA1, BRCA2 in breast cancer and APC, MLH1, MSH2 in colon cancer have been identified.
However, there are many men and women who have a strong family of cancer for whom we cannot provide answers because no mutation is found in known genes.Objectives: i) To identify new candidate breast cancer susceptibility loci by an innovative combi…
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