CORDIS Project
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This project focuses on developing gene therapy techniques to treat hearing loss, affecting 360 million people globally. It aims to improve gene delivery to inner ear cells using advanced vectors and genome editing, ultimately creating personalized treatments based on patient-specific induced pluripotent stem cells.
To address the substantial financial and social burden caused by hearing loss in 360 million people world-wide, I aim to improve hearing via gene therapy to correct inherited and protect from acquired hearing loss.
In vitro experiments will establish the best vector configurations for transfer of therapeutic genes and miRNAs into inner ear hair cells (HC) and spiral ganglion neurons (SGN).
The efficiency of the best-performing vector designs will then be explored in vivo using fluorescent marker…
MEDIZINISCHE HOCHSCHULE HANNOVER
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