CORDIS Project
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This project explores the signaling pathways of interleukin 7 and its receptor in T-cell acute lymphoblastic leukemia. It aims to provide a comprehensive understanding of these pathways to identify new therapeutic targets for cancer treatment.
Deregulation of signal transduction is a feature of tumor cells and signaling therapies are gaining importance in the growing arsenal against cancer.
However, their full potential can only be achieved once we overcome the limited knowledge on how signaling networks are wired in cancer cells.
Interleukin 7 (IL7) and its receptor (IL7R) are essential for normal T-cell development and function.
However, they can also promote autoimmunity, chronic inflammation and cancer.
We showed that patients wit…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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