CORDIS Project
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This project investigates the metabolic mechanisms underlying intellectual disability and autism spectrum disorder by studying the role of specific transcription factors. Using Drosophila models, it aims to identify metabolic dysregulation and potential therapeutic interventions.
The mechanisms underlying monogenic intellectual disability (ID) and autism spectrum disorder (ASD), affecting >2% of the population, remain poorly understood.
Moreover, most ID/ASD syndromes are still untreatable, the exception being some disorders of metabolic origin.
Therefore, identifying unappreciated metabolic mechanisms underlying the pathophysiology of ID/ASD provides a promising avenue to treatment.Several lines of evidence suggest that the transcription factors FOXP1/2/4 are ID/ASD gen…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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France, Paris
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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