CORDIS Project
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The project aims to create genetically encoded sensors to monitor the activation of GABA receptors in the brain, which are crucial for inhibitory neurotransmission. This innovative approach will allow for non-invasive observation of GABAergic networks, enhancing understanding of their role in various neurological disor…
In mammalian brain the main inhibitory drive is determined by GABAergic synaptic transmission.
Released from presynaptic terminals GABA activate postsynaptic Cl-selective GABAA receptors, which results in hyperpolarization of cells and inhibition of neuronal network.
Dysfunction of GABAA receptors may lead to a number of pathologies, including epilepsy, Alzheimer’s disease, sleep disorders and schizophrenia.
The main approach for functional analysis of GABAA receptors is represented by electroph…
UNIVERSITE D'AIX MARSEILLE
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