CORDIS Project
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This project investigates the role of insulin signaling in immune and non-immune cells, focusing on its impact on immune functions, cytokine release, and vaccine efficacy. By analyzing existing data and conducting laboratory experiments, the study aims to uncover the immune-regulatory functions of insulin and its impli…
Though it has long been known that activated lymphoid cells upregulate insulin receptors, the functional relevance of insulin signalling in immune cells has only recently begun to be explored.
This includes the recent finding that insulin-stimulated activation in the PI3K/Akt/mTOR promotes immunometabolic reprogramming of T cells, thereby promoting antigen-specific immunity.
Similarly, in liver cells, insulin receptors have been shown to translocate to the nucleus where they participate in regul…
KATHOLIEKE UNIVERSITEIT LEUVEN
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