CORDIS Project
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This project investigates how the aging microenvironment affects T lymphocyte function and metabolism, aiming to identify mechanisms that lead to T cell dysfunction. By understanding these interactions, the research seeks to develop strategies to rejuvenate T cell immunity, potentially addressing multiple age-related h…
T lymphocytes play a central role in the immune defense against intruders, and support tissue homeostasis and function.
Strikingly, an aged or dysfunctional T cell immunity is sufficient to promote organ aging and multiple age-related morbidities.
In this proposal we hypothesize that there is a bidirectional relationship between T cells and their in vivo microenvironment that could develop into a vicious cycle under conditions of aging and disease.
While a lot is known about the cellular mechan…
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