CORDIS Project
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This project investigates how immune environment changes affect muscle stem cell function and regeneration in aging. It aims to identify immune signals that regulate muscle stem cell behavior and their lineage commitment, with the goal of enhancing muscle stem cell therapies for age-related decline.
Adult stem cells (SCs) sustain tissue renewal and repair throughout life.
The SC niche is fundamental in the regulation of SC function and an important contributor to SC decline in aging.
While alterations in the tissue’s immune environment are emerging as important contributors to impairments found in aged organs, their contribution to SC dysfunction in aging is unknown.
The skeletal muscle (SkM) is a paradigmatic model to study age-related loss of repair capacity.
Muscle stem cell (MuSC) funct…
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