CORDIS Project
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This project investigates how immune cells recognize necrotic cells and the subsequent immune responses triggered by this recognition. It aims to understand the role of specific receptors in myeloid cells and their implications for diseases characterized by chronic inflammation and immune dysregulation.
Necrosis triggers an inflammatory response driven by macrophages that normally contributes to tissue repair but, under certain conditions, can induce a state of chronic inflammation that forms the basis of many diseases.
In addition, dendritic cell (DC)-mediated presentation of antigens from necrotic cells can trigger adaptive immunity in infection-free situations, such as autoimmunity or therapy-induced tumour rejection.
Recently, we and others have identified the myeloid C-type lectin receptor…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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