CORDIS Project
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This project investigates how certain genes maintain active expression states in human cells, particularly focusing on the role of chromatin during immune memory. By utilizing advanced cell selection techniques and genome editing, it aims to uncover factors that stabilize gene expression in dendritic cells, contributin…
Memory of gene expression states is essential for development and maintenance of tissues.
Chromatin, a protein DNA complex, is implicated in the process.
Local, chromatin feedback loops are involved in maintenance of gene silencing, but analogous mechanisms for preservation of active states are unknown.
In order to reveal feedback loops for active gene expression states it is crucial to uncouple them from ongoing transcription, as it occurs in the case of maintenance of silent states.
Such parti…
UNIWERSYTET GDANSKI
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