CORDIS Project
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This project studies dendritic cells and their role in immune responses, particularly how they regulate inflammation through the NF-κB signaling pathway. It aims to understand the implications of ubiquitin modification in allergic and autoimmune conditions.
Dendritic cells (DCs) are strategically positioned as sentinels that process antigens and present these to other immune cells, thereby acting as crucial messengers between innate and adaptive immunity.
DCs are activated by various receptors, including Toll-like receptors (TLRs) that recognize microbial products.
TLR stimulation leads to activation of the transcription factor NF-κB, which is the key regulator of pro-inflammatory genes.
NF-κB activation is tightly regulated by ubiquitination, a mo…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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