CORDIS Project
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This project investigates the interplay between immune cells and mechanical environments during bone regeneration, aiming to reduce scarring. By engineering synthetic niches, it seeks to control cell interactions and improve healing outcomes through a better understanding of immune-mechanical dynamics.
Both scar formation and restitutio ad integrum during bone regeneration rely on cellular self-organisation that involve cell contraction and fibronectin/collagen formation.
This early stage of cellular self-organization is later followed by angiogenesis and mineralisation.
Scar-free regeneration of physiological tissue homeostasis requires balanced downregulation of early inflammation, however little is understood of the immune-mechanical coupling involved.
We aim to lay the foundation for reduc…
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