CORDIS Project
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The IMMUNO-TEX project aims to develop a novel therapeutic platform using tumor-derived immunostimulatory extracellular vesicles to enhance cancer immunotherapy. By generating these vesicles, the project seeks to improve T-cell activation and overcome resistance in patients with poorly immunogenic tumors.
Tumor immunotherapy with immune checkpoint inhibitors (ICI) has unprecedented therapeutic potential, but its success is limited to a minority of patients with preexisting antitumor T-cell immunity.
For patients with poorly-immunogenic tumors, combinatorial immunotherapies are urgently needed.
With a vast and bioactive cargo (proteins, lipids, nucleic acids), extracellular vesicles (EVs) have intrinsic property to regulate complex pathways in distant target cells.
Even though they can transfer tu…
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
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