CORDIS Project
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The IMMUNOBAT project investigates the role of immune cells in brown adipose tissue function and metabolism, particularly in the context of obesity. By analyzing immune cell profiles in human samples, the project aims to understand how these cells influence brown fat activity and explore potential therapeutic strategie…
Brown adipose tissue (BAT) is a promising therapeutic target to improve cardiometabolic health.
However, BAT metabolism is dysfunctional in obesity.
Hence, it is highly relevant to ascertain which mechanisms modulate BAT function and how it can be improved in this context.Mice studies indicate that the immune cells-brown adipocytes molecular interactions within BAT modulate its function.
Indeed, mice knockout for the transcript Mecp2 in BAT macrophages show impaired BAT function and develop obes…
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